Tech Newsletter #2: More loci, more assistance, more details

Presented: DRB3/4/5, DQA1, DPA1, MICA and MICB

We are happy to announce, that DRB3/4/5, DQA1, DPA1, MICA and MICB are now supported as peptide sources. Mismatches between patient and donor occurring on these loci will be included in the PIRCHE analysis. This allows us to predict foreign allo-peptides even for 5- or 6-loci matched cases. This update is now available to all PIRCHE csv modules.

Where is it from?

The solid organ PIRCHE modules are now showing you the PIRCHE score per locus, per presenting molecule and even per mismatch. This allowed us to consider identical peptides from different mismatches as duplicates, giving more precise scores.


All on board the tour bus

You don’t know what modules there are? Now you’ll find previews for all available PIRCHE modules in the sidebar. But if you like, we can also show you around: Take the tour and see what’s there and how it’s used.



Serologic or molecular

Our extrapolation of low resolution typings now allows you to select between serologic and molecular typing inputs. This improves accuracy of imputation and therefore refines overall prediction.

Matthias Niemann

Matthias Niemann

Matthias holds a Masters degree in Computer Science with a major in software engineering and a minor in Bioinformatics from Berlin University (Freie Universität). While working at Charité University Hospital in Berlin, he developed a database for kidney transplantation data and worked on various laboratory information systems and research databases. His research at Charité focused on epitope matching models and machine learning. He was instrumental in the implementation methods to increase data quality.
Since fall 2014 he focuses at PIRCHE on further improving the PIRCHE algorithm and investigating the technology's power in new domains.
Matthias Niemann